Clinical References
Below you will find a list of the studies referenced in this website. Click on View abstract to read more.
Beck DE. Small bowel obstruction and adhesions.
Clin Colon Rectal Surg. 2003;16(3):189-198.
Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG; for Adhesion Study Group Steering Committee. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm® Adhesion Barrier in abdominopelvic surgery of the intestine.
Dis Colon Rectum. 2003;46(10):1310-1319.
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Becker JM, Dayton MT, Fazio VW, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study.
J Am Coll Surg. 1996;183(4):297-306.
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Behera M, Vilos GA, Hollett-Caines J, Abu-Rafea B, Ahmad R. Laparoscopic findings, histopathologic evaluation, and clinical outcomes in women with chronic pelvic pain after hysterectomy and bilateral salpingo-oophorectomy.
J Minim Invasive Gynecol. 2006;13(5):431-435.
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Bristow RE, Montz FJ. Prevention of adhesion formation after radical oophorectomy using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier.
Gynecol Oncol. 2005;99(2):301-308.
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Bristow RE, Santillan A, Diaz-Montes TP, Gardner GJ, Giuntoli RL II, Peeler ST. Prevention of adhesion formation after radical hysterectomy using a sodium hyaluronate- carboxymethylcellulose (HA-CMC) barrier: a cost-effectiveness analysis.
Gynecol Oncol. 2007;104(3):739-746.
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Coleman MG, McLain AD, Moran BJ. Impact of previous surgery on time taken for incision and division of adhesions during laparotomy.
Dis Colon Rectum. 2000;43(9):1297-1299.
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Diamond MP. Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study.
Fertil Steril. 1996;66(6):904-910.
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diZerega GS. Peritoneal repair and postsurgical adhesion formation. In: Mishell DR, Goodwin TM, Brenner PF, eds. Management of
Common Problems in Obstetrics and Gynecology. 4th ed. Malden, MA: Blackwell Science Inc; 2002:267-271.
Eifel PJ. Radiation therapy. In: Berek JS, Hacker NF, eds.
Practical Gynecologic Oncology, 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005:119-161.
Ellis H, Moran BJ, Thompson JN, et al. Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study.
Lancet. 1999;353(9163):1476-1480.
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Fazio VW, Cohen Z, Fleshman JW, et al. Reduction in adhesive small-bowel obstruction by Seprafilm Adhesion Barrier after intestinal resection.
Dis Colon Rectum. 2006;49(1):1-11.
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Fushiki H, Ikoma T, Kobayashi H, Yoshimoto H. Efficacy of Seprafilm as an adhesion prevention barrier in cesarean sections.
Obstet Gynecol Treatment. 2005;91(5):557-561.
Hamel K. Incidence of adhesions at repeat cesarean delivery.
Am J Obstet Gynecol. 2007;196(5):e31-e32.
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Hamilton BE, Martin JA, Ventura SJ. Births: preliminary data for 2006.
Natl Vital Stat Rep. 2007; 56(7):1-18.
Hershlag A, Diamond MP, DeCherney AH. Adhesiolysis.
Clin Obstet Gynecol. 1991;34(2):395-402.
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Keltz MD, Gera PS, Olive DL. Prospective randomized trial of right-sided paracolic adhesiolysis for chronic pelvic pain.
J Soc Laparoendosc Surg. 2006;10(4):443-446.
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Kusunoki M, Ikeuchi H, Yanagi H, et al. Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial.
Surg Today. 2005;35(11):940-945.
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Lyell DJ, Caughey AB, Hu E, Daniels K. Peritoneal closure at primary cesarean delivery and adhesions.
Obstet Gynecol. 2005;106(2):275-280.
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MacDorman MF, Menacker F, Declercq E. Cesarean birth in the United States: epidemiology, trends, and outcomes.
Clin Perinatol. 2008;35:239-307.
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Makoha FW, Felimban HM, Fathuddien MA, Roomi F, Ghabra T. Multiple cesarean section morbidity.
Int J Gynecol Obstet. 2004;87(3):227-232.
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Menzies D, Ellis H. Intestinal obstruction from adhesions—how big is the problem?
Ann R Coll Surg Engl. 1990;72(1):60-63.
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Mohri Y, Uchida K, Araki T, et al. Hyaluronic acid–carboxycellulose membrane (Seprafilm) reduces early postoperative small bowel obstruction in gastrointestinal surgery.
Am Surg. 2005;71(10):861-863.
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Monk BJ, Berman ML, Montz FJ. Adhesions after extensive gynecologic surgery: clinical significance, etiology, and prevention.
Am J Obstet Gynecol. 1994;170(5, pt 1):1396-1403.
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Morales KJ, Gordon MC, Bates GW Jr. Postcesarean delivery adhesions associated with delayed delivery of infant.
Am J Obstet Gynecol. 2007;196(5):461.e1-461.e6.
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Myers SA, Bennett TL. Incidence of significant adhesions at repeat cesarean section and the relationship to method of prior peritoneal closure.
J Reprod Med. 2005;50(9):659-662.
View Abstract
Nichols DH, Clarke-Pearson DL, eds.
Gynecologic, Obstetric, and Related Surgery. 2nd ed. St. Louis, MO: Mosby; 2000.
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Nielsen TF, Hökegård KH. Postoperative cesarean section morbidity: a prospective study.
Am J Obstet Gynecol. 1983;146(8):911-916.
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Raftery AT. Regeneration of parietal and visceral peritoneum: an electron microscopical study.
J Anat. 1973;115(3):375-392.
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Ratcliff JB, Kapernick P, Brooks GG, Dunnihoo DR. Small bowel obstruction and previous gynecologic surgery.
South Med J. 1983;76(11):1349-1350, 1360.
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Ray NF, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1998.
J Am Coll Surg. 1998;186(1):1-9.
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Scovill WA. Small bowel obstruction. In: Cameron JL, ed.
Current Therapy in Surgery. St Louis, MO: Mosby Yearbook Medical Publishers; 1995:100-104.
Stovall TG, Elder RF, Ling FW. Predictors of pelvic adhesions.
J Reprod Med. 1989;34(5):345-348.
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Stricker B, Blanco J, Fox HE. The gynecologic contribution to intestinal obstruction in females.
J Am Coll Surg. 1994;178(6):617-620.
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Tang C-L, Seow-Choen F, Fook-Chong S, Eu K-W. Bioresorbable adhesion barrier facilitates early closure of the defunctioning ileostomy after rectal excision: a prospective, randomized trial.
Dis Colon Rectum. 2003;46(9):1200-1207.
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Tulandi T, Agdi M, Zarei A, Miner L, Sikirica V. Adhesion development and morbidity after repeat cesarean delivery.
Am J Obstet Gynecol. 2009;201(1):56.e1-56.e6.
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van der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MMPJ, Schaapveld M, van Goor H. Morbidity and mortality of inadvertent enterotomy during adhesiotomy.
Br J Surg. 2000;87(4):467-471.
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Yamashita H, Nakagawa K, Tago M, et al. Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma; report of seven cases.
J Obstet Gynaecol Res. 2006;32(2):235-242.
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Indication
Seprafilm® Adhesion Barrier is indicated for the reduction of post-surgical adhesions in patients undergoing abdominal or pelvic laparotomy.
Important Safety Information
Seprafilm should not be wrapped around an intestinal anastomosis as such usage may result in increased anastomotic leak related events, such as abscess or peritonitis. The safety and effectiveness of Seprafilm has not been established in combination with other adhesion prevention products and/or in surgical procedures not within the abdominopelvic cavity. The safety and effectiveness of Seprafilm has also not been evaluated in cases of pregnancy, malignancy, or frank infection. The type and frequency of adverse events reported are consistent with events typically seen following abdominopelvic surgery when used as directed.
Please see full prescribing information.