About Seprafilm

Seprafilm is a temporary, bioresorbable adhesion barrier proven to reduce the incidence, extent, and severity of adhesions in patients undergoing abdominal or pelvic laparotomy.1-3 Seprafilm serves as a temporary bioresorbable barrier separating apposing tissue surfaces. The physical presence of the membrane separates adhesiogenic tissue while the normal tissue repair process takes place.3

Seprafilm is shown to reduce the incidence, extent, and severity of adhesions in a range of abdominal and abdominopelvic procedures, not limited to but including
- Myomectomy2
- Radical oophorectomy4
- C-Section5

Order Seprafilm

To order Seprafilm for your operating room, or to request a product demonstration, call 1-800-261-1570 and select option 1, or fill out an order form.

Seprafilm safety

Seprafilm is proven safe and effective – even in cases not achieving meticulous hemostasis, but we do recommend the field being as dry as possible.1,3,4 

Review safety >>

Clinical benefits

Seprafilm has been studied in more than 4000 patients in 40 published clinical trials.6 

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Indication
Seprafilm® Adhesion Barrier is indicated for the reduction of post-surgical adhesions in patients undergoing abdominal or pelvic laparotomy.

Important Safety Information
Seprafilm should not be wrapped around an intestinal anastomosis as such usage may result in increased anastomotic leak related events, such as abscess or peritonitis. The safety and effectiveness of Seprafilm has not been established in combination with other adhesion prevention products and/or in surgical procedures not within the abdominopelvic cavity. The safety and effectiveness of Seprafilm has also not been evaluated in cases of pregnancy, malignancy, or frank infection. The type and frequency of adverse events reported are consistent with events typically seen following abdominopelvic surgery when used as directed.

Please see full prescribing information.

References

  1. Becker JM, Dayton MT, Fazio VW, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg. 1996;183(4):297-306.
  2. Diamond MP. Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Fertil: Steril 1996;66(6);904-910.
  3. Seprafilm Adhesion Barrier [package insert]. Cambridge, MA: Genzyme Biosurgery; 2008.
  4. Bristow RE, Montz FJ. Prevention of adhesion formation after radical oophorectomy using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier. Gynecol Oncol. 2005;99(2):301-308.
  5. Fushiki H, Ikoma T, Kobayashi H, Yoshimoto H. Efficacy of Seprafilm as an adhesion prevention barrier in cesarean sections. Obstet Gynecol Treatment. 2005;91(5):557-561.
  6. Data on file, Genzyme Corp.