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SEPRAFILM® and Trauma Surgery

Adhesions are a common consequence of abdominal surgery, forming in 93% of patients who undergo abdominal laparotomy.1 Trauma patients may undergo a series of restorative abdominal surgeries, which may be increasingly complicated by the presence of adhesions. In addition, potential for adhesive small bowel obstruction is relatively high due to the extent of tissue manipulation. Moreover, patients who are admitted for violent trauma may be readmitted for future surgery that may be complicated by the presence of adhesions.

Cement belly photo
"Concrete abdomen" - cohesive adhesions between loops of small bowel

The effects of adhesions on subsequent surgery may include:

  • Increased procedure and re-entry time3
  • Difficulty differentiating and accessing tissue planes4
  • Increased risk of inadvertent enterotomy5

For patients, the consequences of adhesions can be serious. Adhesions account for up to:

  • 75% of small bowel obstructions6
  • 40% of infertility cases7
  • 48% of chronic pelvic pain cases8
1. Menzies D, Ellis H. Intestinal obstruction from adhesions—how big is the problem? Ann R Coll Surg Engl. 1990;72:60-63.
 
3. Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, et al.  Adhesion-related hospital readmissions after abdominal and pelvic surgery:  a retrospective cohort study. Lancet1999;353(9163):1476-1480.
 
4. Nichols DH, Clarke-Pearson DL, eds. Gynecologic, Obstetric, and Related Surgery. 2nd ed. St. Louis, MO: Mosby, Inc; 1993.
 
5. Van der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MMPJ, Schaapveld M, van Goor H.  Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg. 2000;87(4):467-471.
 
6. Scovill WA. Small bowel obstruction. In: Cameron JL, ed. Current Therapy in Surgery. St Louis, MO: Mosby Yearbook Medical Publishers, Inc; 1995:100-104.
 
7. DiZerega GS.  Peritoneal repair and postsurgical adhesion formation. In: Management of Common Problems in Obstetrics & Gynecology. Mishell DR, Goodwin Murphy T, Brenner PF, eds. Malden, MA: Blackwell Publishing; 2002: 267-271.
 
8. Stovall TG, Elder RF, Ling FW. Predictors of pelvic adhesions. J Reprod Med. 1989;34:345-348.
 

 

SEPRAFILM Application in Abdominal and Colorectal Procedures

Physician Testimonials

 

Indication

Seprafilm® Adhesion Barrier is indicated for the reduction of post-surgical adhesions in patients undergoing abdominal or pelvic laparotomy.

Important Safety Information

Seprafilm should not be wrapped around an intestinal anastomosis as such usage may result in increased anastomotic leak related events, such as abscess or peritonitis. The safety and effectiveness of Seprafilm has not been established in combination with other adhesion prevention products and/or in surgical procedures not within the abdominopelvic cavity. The safety and effectiveness of Seprafilm has also not been evaluated in cases of pregnancy, malignancy, or frank infection. The type and frequency of adverse events reported are consistent with events typically seen following abdominopelvic surgery when used as directed.

Please see full prescribing information.

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