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Adhesions and Radical Pelvic Surgery
Seprafilm-treated pelvis at second look following radical oophorectomy12 Adhesions are a common consequence of pelvic surgery, forming after up to 95% of gynecologic laparotomies.1 Adhesions are the leading cause of small bowel obstruction following radical pelvic surgery2 and can complicate future surgeries, making it difficult to identify, reach, and separate tissues.3 Because they can obstruct areas of the abdominopelvic cavity, adhesions may limit future treatment options:
Additionally, they account for up to 48% of chronic pelvic pain cases6 and 75% of small bowel obstructions.7 SEPRAFILM® Adhesion Barrier is proven to help prevent postoperative adhesions.8 In recent studies, SEPRAFILM was shown to reduce adhesions observed at subsequent surgeries, resulting in:
SEPRAFILM can be used to reduce adhesions following radical pelvic surgery.  
1. DiZerega GS. Peritoneal repair and postsurgical adhesion formation. In: Management of Common Problems in Obstetrics & Gynecology. Mishell DR, Goodwin Murphy T, Brenner PF, eds. Malden, MA: Blackwell Publishing; 2002: 267-271.
2. Stricker B, Blanco J, Fox H. The gynecologic contribution to intestinal obstruction in females. J Am Col Surg. 1999;178:617-620.
3. Nichols DH, Clarke-Pearson DL, eds. Gynecologic, Obstetric, and Related Surgery. 2nd ed. St. Louis, MO: Mosby, Inc; 1993.
3. Nichols DH, Clarke-Pearson DL, eds. Gynecologic, Obstetric, and Related Surgery. 2nd ed. St. Louis, MO: Mosby, Inc; 1993.
3. Nichols DH, Clarke-Pearson DL, eds. Gynecologic, Obstetric, and Related Surgery. 2nd ed. St. Louis, MO: Mosby, Inc; 1993.
5. Yamashita H, Nakagawa K, Tago M, et al. Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma; report of seven cases. J Obstet Gynecol Res. 2006;32:235-242.
6. Stovall TG, Elder RF, Ling FW. Predictors of pelvic adhesions. J Reprod Med. 1989;34:345-348.
7. Scovill WA. Small bowel obstruction. In: Cameron JL, ed. Current Therapy in Surgery. St Louis, MO: Mosby Yearbook Medical Publishers, Inc; 1995:100-104.
8. SEPRAFILM Prescribing Information. Cambridge, MA: Genzyme Biosurgery; 2007
9. Tang C-L, Seow-Choen F, Fook-Chong S, Eu K-W. Bioresorbable adhesion barrier facilitates early closure of the defunctioning ileostomy after rectal excision. Dis Colon Rectum. 2003;46:1200-1207.
11. Fushiki H, Ikoma T, Kobayashi H, Yoshimoto H. Efficacy of SEPRAFILM as an Adhesion Barrier in Cesarean Sections. Obstetric and Gynecological Treatment [Japanese]. 2005;91(5):557-561.
11. Fushiki H, Ikoma T, Kobayashi H, Yoshimoto H. Efficacy of SEPRAFILM as an Adhesion Barrier in Cesarean Sections. Obstetric and Gynecological Treatment [Japanese]. 2005;91(5):557-561.
12. Bristow RE, Montz FJ. Prevention of adhesion formation after radical oophorectomy using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier. Gynecol Oncol. 2005;99:301-308.
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