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| Healthcare Professionals: Home > Surgical Specialities > SEPRAFILM & Colorectal Surgery > SEPRAFILM & Ostomy Creation and Closure |
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SEPRAFILM® and Ostomy Creation and Closure
Midline and peristomal adhesions can complicate reversal of a colostomy or ileostomy. Additionally, bowel adhesions to the peristomal site following closure can cause adhesive small bowel obstruction. In a series of randomized controlled studies of patients receiving SEPRAFILM at primary radical colorectal resection, SEPRAFILM reduced midline and peristomal adhesions, reducing overall complexity including:
SEPRAFILM is shown to reduce severity and extent of adhesions to the peristomal incision and the need to extend the incision at ileostomy closure.1 Click here for relevant clinical studies. 
Seprafilm wrapping: protecting an ileostomy from adhesions SEPRAFILM application sites in ostomy creation3:
 
1. Kusunoki M, Ikeuchi H, Yanagi H, et al. Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial. Surg Today. 2005;35:940-945.
1. Kusunoki M, Ikeuchi H, Yanagi H, et al. Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial. Surg Today. 2005;35:940-945.
1. Kusunoki M, Ikeuchi H, Yanagi H, et al. Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial. Surg Today. 2005;35:940-945.
2. Tang C-L, Seow-Choen F, Fook-Chong S, Eu K-W. Bioresorbable adhesion barrier facilitates early closure of the defunctioning ileostomy after rectal excision. Dis Colon Rectum. 2003;46:1200-1207.
3. SEPRAFILM Prescribing Information. Cambridge, MA: Genzyme Biosurgery; 2007
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