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Clinical References

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Research Bibliography


Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG, for the Adhesion Study Group Steering Committee. A prospective, randomized, multicenter, controlled study of the safety of Seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum. 2003; 46:1310-1319.
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Becker JM, Dayton MT, Fazio VW, et al. Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg. 1996;183:297-306.
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Behera M, Vilos G, Hollett-Caines J, Abu-Rafea B, Ahmad R. Laparoscopic findings, histopathologic evaluation, and clinical outcomes in women with chronic pelvic pain after hysterectomy and bilateral salpingo-oophorectomy. J Minim Invasive Gynecol. 2006;13(5):431-5.
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Bristow RE, Montz FJ. Prevention of adhesion formation after radical oophorectomy using a sodium hyaluronate-carboxymethylcellulose (HA-CMC) barrier. Gynecol Oncol. 2005;99:301-308.
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Coleman MG, McLain AD, Moran BJ. Impact of Previous Surgery on Time Taken for Incision and Division of Adhesions During Laparotomy. Dis Colon Rectum. 2000;1297-1299.
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Diamond MP. Reduction of adhesions after uterine myomectomy by SEPRAFILM membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Fert Steril. 1996;66(6):904-910.
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DiZerega GS.  Peritoneal repair and postsurgical adhesion formation. In: Management of Common Problems in Obstetrics & Gynecology. Mishell DR, Goodwin Murphy T, Brenner PF, eds. Malden, MA: Blackwell Publishing; 2002: 267-271.

Eifel PF.  Radiation therapy. In: Berek JS, Hacker NF, eds. Practical Gynecologic Oncology, 4th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005: 119-161.

Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, et al.  Adhesion-related hospital readmissions after abdominal and pelvic surgery:  a retrospective cohort study. Lancet1999;353(9163):1476-1480.
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Fazio VW, Cohen Z, Fleshman JW, et al. Reduction in adhesive small-bowel obstruction by Seprafilm Adhesion Barrier after intestinal resection. Dis Colon Rectum. 2005;49:1-11.
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Fox Ray N, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: Inpatient care and expenditures in the United States in 1994. JAm Coll Surg. 1998;186(1):1-9.
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Fushiki H, Ikoma T, Kobayashi H, Yoshimoto H. Efficacy of SEPRAFILM as an Adhesion Barrier in Cesarean Sections. Obstetric and Gynecological Treatment [Japanese]. 2005;91(5):557-561.

Keltz MD, Gera PS, Olive DL.  Prospective randomized trial of right-sided paracolic adhesiolysis for chronic pelvic pain. JSLS. 2006;10(4):443-446.
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Kusunoki M, Ikeuchi H, Yanagi H, et al. Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomized clinical trial. Surg Today.
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Lyell DJ, Caughey AB, Hu E, Daniels K. Peritoneal closure at primary Cesarean delivery and adhesions. Obstet Gynecol. 2005;106:275-80.  2005;35:940-945. 
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Menzies D, Ellis H. Intestinal obstruction from adhesions—how big is the problem? Ann R Coll Surg Engl. 1990;72:60-63.
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Monk BJ, Berman ML, Montz FJ. Adhesions after extensive gynecologic surgery: clinical significance, etiology, and prevention. Am J Obstet Gynec. 1994;170(5): 1396-1403.
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Morales KJ, Gordon MC, Bates GW Jr. Postcesarean delivery adhesions associated with delayed delivery of infant. Am J Obstet Gynecol. 2007;196:461.e1-461.e6.
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Nichols DH, Clarke-Pearson DL, eds. Gynecologic, Obstetric, and Related Surgery. 2nd ed. St. Louis, MO: Mosby, Inc; 1993.

Raftery AT. Regeneration of parietal and visceral peritoneum: an electron microscopical study. J Anat. 1973;115:375-392.
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Ratcliff J, Kapernick P, Brooks G, Dunnihoo D. Small Bowel Obstruction and Previous Gynecologic Surgery. Southern Medical Journal. 1983;76(11):1349-1350.
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Scovill WA. Small bowel obstruction. In: Cameron JL, ed. Current Therapy in Surgery. St Louis, MO: Mosby Yearbook Medical Publishers, Inc; 1995:100-104.

Stovall TG, Elder RF, Ling FW. Predictors of pelvic adhesions. J Reprod Med. 1989;34:345-348.
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Stricker B, Blanco J, Fox H. The gynecologic contribution to intestinal obstruction in females. J Am Col Surg. 1999;178:617-620.
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Tang C-L, Seow-Choen F, Fook-Chong S, Eu K-W. Bioresorbable adhesion barrier facilitates early closure of the defunctioning ileostomy after rectal excision. Dis Colon Rectum. 2003;46:1200-1207.
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Van der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MMPJ, Schaapveld M, van Goor H.  Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg. 2000;87(4):467-471.
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Yamashita H, Nakagawa K, Tago M, et al. Small bowel perforation without tumor recurrence after radiotherapy for cervical carcinoma; report of seven cases. J Obstet Gynecol Res. 2006;32:235-242.
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Indication

Seprafilm® Adhesion Barrier is indicated for the reduction of post-surgical adhesions in patients undergoing abdominal or pelvic laparotomy.

Important Safety Information

Seprafilm should not be wrapped around an intestinal anastomosis as such usage may result in increased anastomotic leak related events, such as abscess or peritonitis. The safety and effectiveness of Seprafilm has not been established in combination with other adhesion prevention products and/or in surgical procedures not within the abdominopelvic cavity. The safety and effectiveness of Seprafilm has also not been evaluated in cases of pregnancy, malignancy, or frank infection. The type and frequency of adverse events reported are consistent with events typically seen following abdominopelvic surgery when used as directed.

Please see full prescribing information.

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